| Â | IV Challenge | Single Mosquito Bite e) |
|---|
| Â |
Average
|
Standard
|
Success
|
Average
|
Standard
|
Success
|
Mouse Strains Tested
|
LD(50)
a)
|
Error
|
Rate
b)
|
% Infected
|
Error
|
Rate
|
BALB/c (Success) | 50c) | 15 | 63% | 98 d) | 1.3 | 80% |
BALB/c (Failed) | 259 c) | 78 | N/A | 75 d) | 5 | N/A |
C57BL/6 | 19 c) | 0 | 100% | 100 d) | 0 | 100% |
ICR (CD-1) | 18 c) | 0 | 100% | 100 d) | 0 | 100% |
- a) ID50's were calculated by the Reed-Muench method [46]
- b) Success was defined as 90% or better of the naïve animals (challenge controls) being infected
- c) Data obtained from 18 (BALB/c) or two (C57BL/6 and ICR (CD-1)) independent IV challenge experiments
- d) Data obtained from 11 (BALB/c) or two (C57BL/6 and ICR (CD-1)) independent mosquito bite challenge experiments
- e) Mice were challenged by a single infected female mosquito in the presence of two male mosquitoes (as described in Table 2)
