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Table 5 Effect of IV challenge dose on perceived vaccine efficacy

From: Comparison of Plasmodium berghei challenge models for the evaluation of pre-erythrocytic malaria vaccines and their effect on perceived vaccine efficacy

 

pcDNAa)

pCSP(-A) a)

Challenge

Infected/total

Infected/total

Efficacy

10,000 SPZ/IV

10/10

8/10

20%

3000 SPZ/IV

9/9

7/10

22%

1000 SPZ/IV

8/10

7/10

12.5%

300 SPZ/IV

9/10

5/10

44%

100 SPZ/IV

7/10

0/10

100%

5000 SPZ/SQ

9/10

0/10

100%

  1. a) Three DNA immunizations of BALB/c mice delivered by gene gun (3 shots/immunization, 1 μg plasmid/shot), empty control plasmid (pcDNA) or CSP-encoding plasmid (plasmid and immunization described previously [30, 34]. All animals were challenged with sporozoites from the same batch of infected mosquitoes. Results were confirmed in independent repeat experiments