| pcDNAa) | pCSP(-A) a) |
---|
Challenge
|
Infected/total
|
Infected/total
|
Efficacy
|
---|
10,000 SPZ/IV | 10/10 | 8/10 | 20% |
3000 SPZ/IV | 9/9 | 7/10 | 22% |
1000 SPZ/IV | 8/10 | 7/10 | 12.5% |
300 SPZ/IV | 9/10 | 5/10 | 44% |
100 SPZ/IV | 7/10 | 0/10 | 100% |
5000 SPZ/SQ | 9/10 | 0/10 | 100% |
- a) Three DNA immunizations of BALB/c mice delivered by gene gun (3 shots/immunization, 1 μg plasmid/shot), empty control plasmid (pcDNA) or CSP-encoding plasmid (plasmid and immunization described previously [30, 34]. All animals were challenged with sporozoites from the same batch of infected mosquitoes. Results were confirmed in independent repeat experiments