Combined effects of specific PPI that could contribute to events and processes in CM pathology. a) PfEMP1 presentation: Parasite Hsps - KAHRP/ETRAMP interactions during high temperature and the PPI between apolipoproteins and ETRAMP. b) Platelet activation: PPI between platelet membrane glycoprotein IIIa (gpIIIa) and merozoite surface proteins MSP1 and MSP8 resulting in TGF-β release. TGF-β released by activated platelets is activated by parasite protein PfTRAP. PPI between parasite proteins and TGF-β-TGF-β receptors TGFBR1, TGFBR2 might interfere in the anti-inflammatory role of TGF-β c) Astrocyte dysfunction: PPI between albumin and TGF-β receptors.