Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection

Table 3 Summary of power analysis.

	M: infected (inf) vs uninfected (uninf)				S1: infected vs uninfected				S2: infected vs uninfected
	h^a	N_inf ^b	N_uninf ^b	power^c	h^a	N_inf ^b	N_uninf ^b	power	h^a	N_inf ^b	N_uninf ^b	power^c
Ins32	0.898	30	62	0.548	0.443				0.434
Ins33	0.615	65	127		0.440				0.317
Ins34	1.146	21	30	0.85	0.254				0.563	77	154
Ins35	0.780	40	81		0.481				0.288
Mkk41	0.694	51	100		0.452				0.634	61	120
Mkk43	0.340				0.583	72	143		0.636	60	122
Toll5B1	1.558	10	20	0.995	2.116	6	9	1	0.344
Toll5B2	-				0.269				0.344
Toll5B3	0.576	74	145		0.357				0.485
Toll5B4	0.380				0.415				0.321
Toll5B6	0.514	83	183		1.292	15	27	1	0.627	62	124
Actual number genotyped		25	30			58	50			37	38
	M vs S1				S1 vs S2				M vs S2
	h^a	M^b	S1^b	power^c	h^a	S1^b	S2^b	power	h^a	S1^b	S2^b	power^c
Ins32	0.085				0.305				0.289
Ins33	0.348				0.415				0.192
Ins34	0.155				0.465				0.423
Ins35	0.270				0.626	93	75	0.834	0.701	55	83	0.775
Mkk41	0.755	55	59	0.914	0.241				0.745	55	62	0.842
Mkk43	0.354				0.261				0.566	90	116	0.497
Toll5B1	0.344				0.737	75	50	0.956	0.870	55	35	0.956
Toll5B2	0.151				0.091				-
Toll5B3	0.178				0.294				0.347
Toll5B4	0.550	81	160	0.55	-				0.561	90	121	0.486
Toll5B6	-				0.384				0.456
Actual number genotyped		55	108			108	75			55	75

^aEffect size. ^b For SNPs for which effect size was greater than 0.5, required sample size to achieve 80% power was calculated. ^c Power given the actual number of genotyped samples. If the actual number of genotyped samples exceeded the required sample size, SNPs are marked in underlined bold text.

ISSN: 1475-2875