Table 2 Associations between nutrient deficiencies and type I cytokine responses to in vitro stimulation of PBMCs with malaria-parasitized red blood cells
| Â | Supernatant concentration (ng/L) after 7 days of stnimlation | |||
|---|---|---|---|---|
Nutrient status | IL-12 | TNF-α | IFN-γ | IL-1b |
Zinc | Â | Â | Â | Â |
Deficient | 2.4 (19) | 4.3 (35) | 46.6 (42) | 4.5 (33) |
Replete | 2.4 (13) | 3.2 (28) | 26.8 (37) | 5.5 (27) |
Effect | -1% [-29% to 38%] | 37%[14% to ll8%] | 74% [24% to 297%] | -19% [-47% to 26%] |
Magnesium | Â | Â | Â | Â |
Deficient | 2.4 (23) | 3.7 (43) | 34.1 (56) | 4.9 (41) |
Replete | 2.3 (9) | 3.9 (20) | 41.1 (23) | 4.8 (19) |
Effect | 4% [-28% to 51%] | -6% [-43% to 57%] | -17% [-66% to 108%] | 3% [-36% to 64%] |