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Table 4 Prevalence of molecular markers of anti-folate resistance among new episodes of P. falciparum malaria

From: Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance

Characteristics HIV-uninfected*
(n = 352)
HIV-infected*
(n = 60)
P-value
Prevalence of dhfr mutations    
   51I 179(99%) 60(100%) 0.563
   59R 163 (91%) 56(93%) 0.510
   108N 180(100%) 60 (100%)  
   164L 1 (1%) 5 (8%) 0.001
Prevalence of dhps mutations    
   437G 172 (96%) 58 (97%) 0.709
   540E 174(97%) 59 (99%) 0.506
Quintuple mutation 154 (86%) 55 (92%) 0.222
  1. *All HIV-uninfected participants were not receiving TS and all HIV-infected participants were receiving daily TS
  2. Assessed in a random sample of 180 episodes matched by malaria treatment and calendar time
  3. dhfr 51I/59R/108N + dhps 437G/540E mutations