Table 1 Baseline characteristics of study participants and clinical and parasite response to treatment
Characteristics | 1998 | 2001 | 2004 - 2005 | 2008 - 2009 |
|---|---|---|---|---|
Antimalarial drugs 1 | ART for 5 days | ART for 7 days | AS for 7 days | AS for 7 days |
Source of drugs | Vietnam | Vietnam | China | Vietnam |
Number of patients | 65 | 69 | 82 | 54 |
Age | 22 ± 13 | 26 ± 13 | 19 ± 14 | 30 ± 14 |
Gender (M/F) | 36/29 | 46/23 | 61/31 | 42/12 |
Temperature (°C) | 38.4 ± 1.1 | 38.6 ± 1.1 | 38.1 ± 1.2 | 38.7 ± 1.1 |
Geometric mean of parasite (Range) | 11,200 1,360 - 129,032 | 13,377 1,120 - 211,200 | 11,444 1,000 - 200,000 | 13,942 1,000 - 155,924 |
Fever Clearance Time (days) Median | 1.4 ± 0.5 1 (1 - 2) | 1.7 ± 0.7 2 (1 - 4) | 1.4 ± 0.6 1 (1 - 3) | 1.4 ± 0.5 1 (1 - 2) |
Parasite Clearance time (days) Median | 1.8 ± 0.9 2 (1 - 3) | 2.3 ± 0.9 2 (1 - 3) | 2.1 ± 0.7 2 (1 - 3) | 1.6 ± 0.7 1 (1 - 3) |
No. with recurrent parasitaemia (%) | 24 (36.9%) | 5 (7.2%) | 6 (7.3%) | 2 (3.7%) |
Treatment failure after genotyping | 9 (13.8%) | 2 (2.9%) | 1 (1.2%) | 0 (0%) |