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Table 3 Results of clinical trials by genotyping modality

From: Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda

Study Location

Treatment Arm

Genotyping-corrected 42-day Risk of Treatment Failure, % (95% CI)

Risk Difference,

Gel vs. CE, % (p value)

  

Gel

CE

 

Kanungu

AL

6.9 (3.8-12.1)

5.5 (2.9-10.3)

1.4 (0.4)

 

DP

2.4 (1.0-5.7)

2.9 (1.3-6.3)

-0.5 (0.5)

Risk Difference,

AL vs. DP, % (p value)

4.5 (0.07)

2.6 (0.3)

 

Apac

AL

17.0 (11.8-24.0)

10.7 (6.6-17.1)

6.3 (0.02)

 

DP

8.5 (5.2-13.7)

3.4 (1.5-7.4)

5.1 (0.03)

Risk Difference,

AL vs. DP, % (p value)

8.5 (0.03)

7.3 (0.02)

 
  1. Risks of treatment failure calculated using the Kaplan-Meier product limit formula; p-values for risk differences calculated from 1,000 bootstrap repetitions.