| Parascreen | Falcivax | Malascan | First Response | ParaHIT Total |
---|---|---|---|---|---|
Light Microscopy as Gold Standard (Reference) | |||||
Sensitivity | 93.2 | 88.4 | 90.5 | 95.8 | 65.8 |
(95% CI) | (88.6-96.3) | (83.0-92.6) | (85.4-94.3) | (91.9-98.2) | (58.6-72.5) |
Specificity | 64.3 | 64.8 | 60.4 | 58.8 | 76.9 |
(95% CI) | (56.9-71.2) | (57.4-71.8) | (52.9-67.6) | (51.3-66.0) | (70.1-82.8) |
Positive Likelihood Ratio | 2.6 | 2.5 | 2.3 | 2.3 | 2.9 |
(95% CI) | (2.1-3.2) | (2.1-3.1) | (1.9-2.8) | (1.9-2.8) | (2.2-3.8) |
Negative Likelihood Ratio | 0.1 | 0.2 | 0.2 | 0.1 | 0.44 |
(95% CI) | (0.1-0.2) | (0.1-0.3) | (0.1-0.3) | (0.04-0.14) | (0.36-0.55) |
Positive Predictive Value | 73.1 | 72.4 | 70.5 | 70.8 | 74.9 |
(95% CI) | (67.1-78.6) | (67.2-78.1) | (64.3-76.1) | (64.8-76.3) | (67.6-81.2) |
Negative Predictive Value | 90.0 | 84.3 | 85.9 | 93.0 | 68.3 |
(95% CI) | (83.5-94.6) | (77.2-89.9) | (78.7-91.4) | (86.8-96.9) | (61.4-74.6) |
Percentage Agreement (Accuracy) | 79.0 | 76.9 | 75.8 | 77.7 | 71.2 |
Kappa | 0.58 | 0.53 | 0.51 | 0.55 | 0.43 |
PCR as Gold Standard (Reference) | |||||
Sensitivity | 86.6 | 83.1 | 85.7 | 89.2 | 61.0 |
(95% CI) | (81.5-90.7) | (77.7-87.7) | (80.5-90.0) | (84.4-92.9) | (54.4-67.4) |
Specificity | 73.7 | 75.2 | 70.7 | 67.7 | 85.0 |
(95% CI) | (65.3-80.9) | (67.0-82.3) | (62.2-78.2) | (59.0-75.5) | (77.7-90.6) |
Positive Likelihood Ratio | 3.3 | 3.4 | 2.9 | 2.8 | 4.1 |
(95% CI) | (2.5-4.4) | (2.5-4.5) | (2.2-3.8) | (2.2-3.5) | (2.7-6.2) |
Negative Likelihood Ratio | 0.2 | 0.2 | 0.2 | 0.2 | 0.46 |
(95% CI) | (0.1-0.3) | (0.2-0.3) | (0.1-0.3) | (0.11-0.24) | (0.38-0.55) |
Positive Predictive Value | 85.1 | 85.3 | 83.5 | 82.7 | 87.6 |
(95% CI) | (79.9-89.4) | (80.0-89.7) | (78.2-88.0) | (77.5-87.2) | (81.5-92.2) |
Negative Predictive Value | 76.0 | 71.9 | 74.0 | 78.3 | 55.7 |
(95% CI) | (67.7-83.1) | (63.7-79.2) | (65.5-81.4) | (69.6-85.4) | (48.5-62.6) |
Percentage Agreement (Accuracy) | 81.9 | 80.2 | 80.2 | 81.3 | 69.8 |
Kappa | 0.61 | 0.58 | 0.57 | 0.59 | 0.41 |