Figure 1

Patterns of blood parasitaemia observed in NOD/SCID mice. In four independent experiments, a total of 84 NOD/SCID mice were infected with a single i.p. infection of P. falciparum 3D7 strain on day 0 and HuRBC (500 μl of pellet at 50% haematocrit), clo-lip (200 μl) and NIMP-R14 (10 mg/kg) antibody were injected i.p. every 3 days as previously described (black arrows). The preparatory phase prior to the injection of infected HuRBC is not shown. Parasitaemia was measured on tail blood smears by counting the number of infected RBC among 10000 total human and mouse RBC. Parasitemia lower than 0,001 are not considered. The figure shows the average parasitaemia ± SD, and the percentages (and number of mice) corresponding to each pattern of parasitemia.