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Figure 3 | Malaria Journal

Figure 3

From: Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria

Figure 3

Effect of punicalagin and EA on MMP-9 secretion (panel A, C) and mRNA levels (B, D) in THP-1 cells stimulated with Hz. Punicalagin at 1 and 10 μM inhibited the release of MMP-9 in Hz stimulated THP-1 cells by 38% and 79%; the MMP-9 mRNA levels decreased accordingly (-47% at 10 μM; Figure 3A-B). EA at 1 and 10 μM inhibited the release of MMP-9 in Hz-stimulated THP-1 cells by 52 and 66%, respectively, and the MMP-9 expression by 56 and 65%, respectively (Figure 3C-D). All experiments were reproduced at least three times. Statistical analyses were performed with GraphPad Prism 5 software, using 1-way ANOVA test followed by Bonferroni's post hoc test. The significance was indicated as follows: ** p < 0.01; *** p < 0.001.

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Malaria Journal

ISSN: 1475-2875

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