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Table 2 Predictors of malaria rapid diagnostic test (RDT) sensitivity (RDT positive, expert microscopy positive) in Blantyre, Malawi, 2009

From: Comparative field performance and adherence to test results of four malaria rapid diagnostic tests among febrile patients more than five years of age in Blantyre, Malawi

  Sensitivity n/N(%) Unadjusted odds ratio (P value) Adjusted odd ratio Model 1 (P value) Adjusted odds ratio Model 2 (P value)
RDT type     
   Bioline SD 188/193 (97) 2.6 (0.17) 2.9 (0.14)  
   First response malaria 185/201 (92) 1.1 (0.82) 1.1 (0.84)  
   Paracheck 118/130 (91) 0.8 (0.63) 0.8 (0.77)  
   ICT diagnostics 98/109 (90) Referent Referent  
Age     
   5 to ≤ 15 yrs 369/382 (97) 4.8 (< 0.001) 5.1 (< 0.001) 5.1 (< 0.001)
   > 15 yrs 206/237 (87) Referent Referent Referent
Temperature     
   ≥ 37.5°C 281/298 (94) 2.1 (0.09) 1.7 (0.23) 1.7 (0.22)
   < 37.5°C 286/310 (92) Referent Referent Referent
Geometric mean parasite density     
   ≥ 5000 per μl 181/193 (94) 1.1 (0.74) 0.7 (0.36) 0.6 (0.32)
   < 5000 per μl 408/440 (93) Referent Referent Referent
Self-treated with antimalarial in past 2 weeks     
   Yes 44/51 (86) 0.9 (0.85) 1.2 (0.82) 2.1 (0.38)
   No 501/538 (93) Referent Referent Referent
RDT performed by:     
   Community health worker 481/507 (95) 2.6 (0.03)   3.1 (0.02)
   Laboratory technician 108/126 (86) Referent   Referent
  1. Model 1 assesses RDT type adjusted for patient age, temperature, parasite density, and self-treatment with anti-malarials.
  2. Model 2 assesses RDT test operator (community health worker versus laboratory technician) adjusted for patient age, temperature, parasite density, and self-treatment with anti-malarials.