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Table 2 Numbers of false-positive test lines for the different Plasmodium antigens of the RDTs when run with blood of malaria free subjects and substitute liquids

From: Buffer substitution in malaria rapid diagnostic tests causes false-positive results

RDT target antigen Numbers of RDT brands (n = 27) detecting the target Total numbers of tests performed with each substitute* Numbers of false positive test lines when run with substitute liquid
Saline Distilled water Tap water
HRP-2 21 98 22 28 36
Pf-pLDH 5 25 8 9 9
Pv-pLDH 9 45 12 21 20
Pan-pLDH 14 70 30 25 33
Aldolase 3 11 1 5 5
  1. *Each RDT brand was assessed with blood of five malaria-free subjects except one HRP-2-based kit and one HRP-2/aldolase-based kit that were assessed with two and one samples respectively.