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Table 1 Scoring chart for definition and severity of ECM disease as per clinical signs.

From: Artemisone effective against murine cerebral malaria

Appearance

Normal

0

 

Coat ruffled

1

 

Coat staring; panting

2

Behaviour (undisturbed)

Normal

0

 

Hunched; wobbly gait

1

 

Partial paralysis; immobile*†

2

 

Convulsions; coma*

3

Food intake

Normal

0

 

Up to 10% loss in body weight

1

 

10%-15%* loss in body weight

2

 

More than 15% loss in body weight*

3

Body temperature

Normal (36-37°C)

0

 

34-35°C

1

 

32-33°C*

2

 

Below 32°C*

3

  1. Mice with a cumulative score of 5 or above are sacrificed, and death deemed to be on the following day.
  2. *Endpoint for mouse sacrifice.
  3. †Also in response to stimulation.