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Table 2 The effect of artemisinin derivatives on the development of experimental cerebral malaria in PbA-infected ICR mice.

From: Artemisone effective against murine cerebral malaria

Compound Dose % ECM Delay to ECM (relative to control)
DMSO 50 μl 50-90%* -
DHA 5 mg/kg/d 90% -
  10 mg/kg/d 70% -
  20 mg/kg/d 60% 2 days
Artesunate 2 × 5 mg/kg/d 65% 9 days**
Artemisone 5 mg/kg/d 100% 2 days
Artemiside 3 mg/kg/d Total cure, no ECM**,† -
  1. Mice (n = 10 mice/group) were treated for two to five days post-inoculation. Death from ECM was apparent in control mice starting on day 7 post-inoculation. Mice which did not die of ECM died of severe anemic malaria.
  2. * In 3 experiments.
  3. ** Significant
  4. No recrudescence