Artemisone effective against murine cerebral malaria

Malaria Journal

Table 2 The effect of artemisinin derivatives on the development of experimental cerebral malaria in PbA-infected ICR mice.

Compound	Dose	% ECM	Delay to ECM (relative to control)
DMSO	50 μl	50-90%*	-
DHA	5 mg/kg/d	90%	-
	10 mg/kg/d	70%	-
	20 mg/kg/d	60%	2 days
Artesunate	2 × 5 mg/kg/d	65%	9 days**
Artemisone	5 mg/kg/d	100%	2 days
Artemiside	3 mg/kg/d	Total cure, no ECM**^,†	-

Mice (n = 10 mice/group) were treated for two to five days post-inoculation. Death from ECM was apparent in control mice starting on day 7 post-inoculation. Mice which did not die of ECM died of severe anemic malaria.
* In 3 experiments.
** Significant
^† No recrudescence

ISSN: 1475-2875