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Table 4 Disease pattern in PbAus-infected C57BL/6 mice treated with artesunate or artemisone twice a day, on days 7-9 post-inoculation.

From: Artemisone effective against murine cerebral malaria

Compound

Dose

Infection outcome

  

Cerebral malaria

Anemic malaria

Cured

DMSO

20 μl

4/8

4/8

0/8

Artesunate

2 × 2.5 mg/kg/d

6/8

2/8

0/8

 

2 × 5 mg/kg/d

1/8*

7/8*

0/8

Artemisone

2 × 2.5 mg/kg/d

0/8*

3/8

5/8*†

 

2 × 5 mg/kg/d

0/8*

0/8*†

8/8*†

  1. *Significant vs. control.
  2. †Significant vs. artesunate.
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Malaria Journal

ISSN: 1475-2875

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