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Table 2 GM/KM phenotypes in relation to IgG subclass-specific antibodies to PvAMA-1 in subjects exposed to malaria

From: Immunoglobulin GM 3 23 5,13,14 phenotype is strongly associated with IgG1 antibody responses to Plasmodium vivax vaccine candidate antigens PvMSP1-19 and PvAMA-1

Phenotypes
(Number of subjects)
Antibody levels (Reactivity Index) (Median, Interquartile range)
  IgG1 IgG2 IgG3 IgG4
GM 1,2,17 21 (10) b0.15(0.10-0.48) 0.02(0.01-0.62) 0.57(0.18-1.04) 0.06(0.01-0.64)
GM 1,17 5,13,14,21 (21) c0.28(0.05-0.58) 0.4(0.05-1.21) 0.47(0.24-1.05) 0.37(0.05-0.75)
GM 1,2,3,17 23 5,13,14,21 (14) 1.09(0.54-3.70) 0.42(0.16-0.88) 0.45(0.26-0.73) 0.23(0.03-0.38)
GM 1,3,17 23 5,13,14,21 (33) d2.02(0.61-3.67) 0.50(0.16-1.23) 0.66(0.31-1.72) 0.58(0.13-0.93)
GM 1,3,17 23 5,6,13,14 (10) 1.68(0.22-3.83) 0.01(0.01-0.30) 0.31(0.01-1.10) 0.60(0.01-0.91)
GM 1,3,17 5,13,14,21 (20) 0.94(0.18-3.98) 0.35(0.01-0.92) 0.47(0.09-1.86) 0.27(0.06-0.92)
GM 3 23 5,13,14 (22) e3.81(1.18-11.78) 0.45(0.01-1.71) 0.76(0.12-1.32) 0.15(0.01-2.30)
aOther GM (80) f0.58(0.11-2.09) 0.39(0.13-1.66) 0.59(0.18-1.09) 0.32(0.03-0.87)
KM 1 (11) 0.71(0.03-1.10) 0.13(0.01-0.44) 0.28(0.10-0.82) 0.47(0.38-0.95)
KM 1,3 (80) 0.67(0.27-1.96) 0.49(0.14-1.09) 0.57(0.23-1.06) 0.33(0.04-0.69)
KM 3 (119) 0.94 (0.19-3.69) 0.37(0.01-1.06) 0.57(0.21-1.14) 0.29(0.03-0.85)
  1. aOther GM [(GM 1,17 21 (n = 5), GM 1,17 5,6,14,21 (n = 5), GM 3 5,13,14 (n = 4), GM 1,17 13,21 (n = 5), GM 1,17 6,14,21 (n = 1), GM 1,2,17 13,21 (n = 5), GM 1,2,17 13,14,21 (n = 3), GM 1,3,17 13,14,21 (n = 2), GM 1,17 23 5,13,14,21 (n = 2), GM 1,17 5,6,13,14 (n = 5), GM 1,17 5,6,13,14,21 (n = 4), GM 1,17 5,14,21 (n = 2), GM 1,2,17 5,6,13,14,21 (n = 2), GM 1,2,17 5,6,14,21 (n = 4), GM 1,2,17 5,6,21 (n = 2), GM 1,2,3,17 5,6,13,14,21 (n = 1), GM 1,3,17 23 5,13,14 (n = 1), GM 1,3,17 23 5,6,13,14,21 (n = 5), GM 1,3,17 5,13,14 (n = 5), GM 1,3,17 5,6,13,14 (n = 5), GM 1,3,17 5,6,13,14,21 (n = 3), GM 1,2,17 5,13,14,21 (n = 4), GM 1,2,3,17 5,13,14,21 (n = 5)]
  2. bsignificantly lower (P = 0.019), csignificantly lower (P = 0.0003), dsignificantly higher (P = 0.007), esignificantly higher (P = 0.002), fsignificantly lower (P = 0.029) (obtained by Wilcoxon-Mann-Whitney test) compared with the rest of the GM phenotypes.