Figure 1

Up-regulation of different chaperone classes in cluster 1 and cluster 2. Organellar chaperones such as mitochondrial Hsp60, apicoplast Cpn60 and apicoplast Hsp90 are over-expressed in cluster 1. Cytosolic chaperones such as Hsp90_C, Hsp40 and Hsp90 co-chaperones are up-regulated in cluster 2. Cluster 3 shows heterogeneous expression of all genes. Yellow bars indicate cluster 1, red bars indicate cluster 2 and blue bars indicate cluster 3. Cytosolic Hsp90 was taken as a criterion for further clustering of cluster 3. Raw Hsp90 expression values for 18 patients of cluster 3 were used for NMF clustering into sub-clusters 3a and 3b. Clustering of PfHsp90 into two clusters suggest that PfHsp90 may be driving development of different states of the parasite.