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Table 7 Summary of the properties of AMA1 epitopes

From: Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

Epitope

HLA-restriction

Amino acids

Sequence

Location

Crystal

face

Accessibility

E1

B44

13-21

FEFTYMINF

Signal

  

E2

B44

35-44

SD VYR PI NEH

Prodomain

  

E3

B08

47-55

HPKE YE YP L

Prodomain

  

E4

B44

51-59

YE YP LHQE H

Prodomain

  

E5

B08

175-183

Y LKDGGFAF

Domain I

F/B

YnaKD

E6

A01

194-202

TLDE+MRHF Y

Domain I

B

D, E, H, F

E7

A01

198-207

MRHF YKD NKY

Domain I

F/B

H, F, D, K, Y

E8

B44

327-335

NE FP AI DLF

Domain II

F/B

E, P, I

E9

A02

339-346

KLVFELS* A

Domain II

F

E, L

E10

A01

389-397

RYKSH GK GY

Domain II

F

H, K, Y

E11

A02

405-414

ETQ KCEIFNV

Domain II

B

E, T, Q, N

E12

A02

406-414

TQ KCEIFNV

Domain II

F

T, Q, N

E13

A02

410-419

EIFNVK*PTCL

Domain II

F

NK

E14

B44

520-528

NEVVVKE* EY

Domain III

F

VEE

  1. Variable amino acids are highlighted in bold.
  2. *Indicated that there is only one variant of <0.001% frequency
  3. E+ is essential for binding of growth inhibitory MAb 1F9
  4. F = front, B = back, F/B = wraps from front to back
  5. Yna Accessibility not available for amino acid Y
  6. Confirmed epitope numbers are indicated in bold