| dhfr codon |  | dhps codon |
---|
 | N51I | C59R | S108N |  | A437G | K540E |
---|
Single | X | Â | Â | Single | X | Â |
 |  | X |  |  |  | X |
 |  |  | X |  |  |  |
Double | X | X | Â | Double | X | X |
 |  | X | X |  |  |  |
 | X |  | X |  |  |  |
Triple | X | X | X | Â | Â | Â |
- Each row represents a mutant genotype for either the dhfr gene or dhps gene. A white box represents a wildtype codon whereas a box with an "X" represents a mutant codon. The MGF database (Additional File 2) reports the frequency of mutant genotypes using the single, double, and triple mutant categories for dhfr and the single and double mutant categories for dhps.