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Table 3 Genotype frequency calculation rubric

From: Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations

 

Mutant Frequency =

Wildtype Frequency =

Mixed Frequency =

Combined

(Mu + Mi)/(Mu + Mi + Wt)

Wt/(Mu + Mi + Wt)

N/A

Excluded

Mu/(Mu + Wt)

Wt/(Mu + Wt)

N/A

Separate

Mu/(Mu + Wt + Mi)

Wt/(Mu + Wt + Mi)

Mi/(Mu + Wt + Mi)

Split (MAF only)

(Mu + Mi)/[Mu + Wt + (2 × Mi)]

(Wt + Mi)/[Mu + Wt + (2 × Mi)]

N/A

N/A

Mi not described.

Mutant frequency reported directly from study

Mi not described.

Wildtype frequency reported directly from study

N/A

  1. Mu = number of isolates carrying pure mutant genotype
  2. Mi = number of isolates carrying mixed mutant genotype
  3. Wt = number of isolates carrying pure wildtype genotype