Declining in efficacy of a three-day combination regimen of mefloquine-artesunate in a multi-drug resistance area along the Thai-Myanmar border

Table 1 Summary of cases included in the study and clinical response.

	Sensitive response	Recrudescence response
N	90	34
Age (yr)	25.0 (18-50)	25.0 (16.0-45.0)
Sex (n: male, female)	47, 43	15, 19
Body weight (kg)	55.0 (39.0-72.0)	52.0 (44.0-73.5)
Admission parasitemia (/ml)	5,232(1,260-84,000)	6,002(2,450-34,300)
Parasitemia on the day of recrudescence (/ml)	-	1,030(120-3,300)
Day of recrudescence (days)	-	28.0 (7.0-42.0)
PCT (hr)	24.0(14.0-32.0)	32.0(20.0-48.0)^a
PCT_{24 hr} (hr: n, %)	56, 62.2^b	6, 17.6
PCT_{48 hr} (hr: n, %)	90, 100	34, 100
FCT (hr)	26.0(18.0-36.0)	30.0(22.0-42.0)^c
FCT_{24 hr} (hr: n, %)	37, 41.1^d	7, 20.5
FCT_{48 hr} (hr: n, %)	90, 100	34, 100

Data are presented as median (95% CI) or proportion (n, %)
^a = Statistically significantly longer than patients with sensitive response (Mann Whitney U-test, p < 0.005)
^b = Statistically significantly higher than patients with recrudescence response (Chi-square test, p < 0.01)
^c = Statistically significantly longer than patients with sensitive response (Mann Whitney U-test, p < 0.005)
^d = Statistically significantly higher than patients with recrudescence response (Chi-square test, p < 0.01)

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