Table 3 Plasma concentrations of artesunate and dihydroartemisinin on day-0 (pre-treatment) and at 1 and 6 hours after treatment in patients with sensitive response and recrudescence.
Drug/Day of treatment | Sensitive response | Recrudescence response | ||
|---|---|---|---|---|
| Â | N | Mean (95%CI)* or Median (95% CI)** | N | Mean (95%CI)* or Median (95% CI)** |
Artesunate: | ||||
Day 0** | 90 | 0 | 35 | 0 |
Hour 1* | 65 | 344 (312-375) | 30 | 323 (282-364) |
Hour 6** | 64 | 1 (0-1,253) | 30 | 0 (0-12) |
Dihydroartemisinin: | ||||
Day 0** | 90 | 0 (0-10) | 35 | 0 |
Hour 1* | 65 | 525 (452-599) | 30 | 456 (215-875)a |
Hour 6** | 64 | 98 (13-220) | 30 | 100 (0-220) |