Table 1 Non-compartmental analysis of artemether and dihydroartemisinin pharmacokinetics in twelve healthy Pakistani subjects
Artemether | Dihydroartemisinin | |||
|---|---|---|---|---|
Mean ± SD | Median (range) | Mean ± SD | Median (range) | |
Body-weight (kg) | 69.9 ± 10 | 69.0 (51.0-83.0) | 69.9 ± 10 | 69.0 (51.0-83.0) |
Dose (mg/kg) | 1.17 ± 0.18 | 1.16 (0.960-1.57) | 1.11 ± 0.17 | 1.10 (0.92-1.49) |
TLAG (hr) | 0.130 ± 0.23 | 0 (0-0.75) | 0.250 ± 0.24 | 0.250 (0-0.75) |
CMAX (ng/mL) | 184 ± 100 | 173 (54.2-363) | 126 ± 46 | 122 (53.7-195) |
CMAX/dose (kg × ng/mL × mg) | 160 ± 86 | 148 (34.6-299) | 113 ± 38 | 107 (57.1-169) |
TMAX (hr) | 1.56 ± 0.68 | 1.50 (0.500-3.00) | 1.69 ± 0.59 | 1.50 (0.750-3.00) |
CL/F (L/hr) | 257 ± 140 | 222 (119-609) | 269 ± 57 | 246 (209-383) |
CL/F (L/hr × kg) | 3.89 ± 2.8 | 3.11 (1.57-11.9) | 3.87 ± 0.74 | 3.70 (3.05-5.27) |
VZ/F (L) | 666 ± 220 | 651 (342-1150) | 702 ± 220 | 643 (456-1190) |
VZ/F (L/kg) | 9.85 ± 4.5 | 8.68 (5.02-22.5) | 10.1 ± 2.6 | 9.63 (6.61-14.6) |
T1/2 (hr) | 2.00 ± 0.71 | 1.88 (1.24-4.00) | 1.80 ± 0.31 | 1.78 (1.34-2.20) |
AUC0-LAST (hr × ng/mL) | 379 ± 170 | 362 (128-664) | 287 ± 60 | 303 (196-361) |
AUC0-∞ (hr × ng/mL) | 385 ± 170 | 370 (131-671) | 294 ± 58 | 311 (199-365) |
AUC0-∞/dose (kg × hr × ng/mL × mg) | 339 ± 160 | 322 (83.8-638) | 267 ± 48 | 270 (190-327) |
Extrapolated AUC0-∞ (%) | 1.75 ± 0.99 | 1.43 (0.90-4.26) | 2.59 ± 2.2 | 1.71 (0.73-8.76) |