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Table 1 Non-compartmental analysis of artemether and dihydroartemisinin pharmacokinetics in twelve healthy Pakistani subjects

From: Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine

  Artemether Dihydroartemisinin
  Mean ± SD Median (range) Mean ± SD Median (range)
Body-weight (kg) 69.9 ± 10 69.0 (51.0-83.0) 69.9 ± 10 69.0 (51.0-83.0)
Dose (mg/kg) 1.17 ± 0.18 1.16 (0.960-1.57) 1.11 ± 0.17 1.10 (0.92-1.49)
TLAG (hr) 0.130 ± 0.23 0 (0-0.75) 0.250 ± 0.24 0.250 (0-0.75)
CMAX (ng/mL) 184 ± 100 173 (54.2-363) 126 ± 46 122 (53.7-195)
CMAX/dose (kg × ng/mL × mg) 160 ± 86 148 (34.6-299) 113 ± 38 107 (57.1-169)
TMAX (hr) 1.56 ± 0.68 1.50 (0.500-3.00) 1.69 ± 0.59 1.50 (0.750-3.00)
CL/F (L/hr) 257 ± 140 222 (119-609) 269 ± 57 246 (209-383)
CL/F (L/hr × kg) 3.89 ± 2.8 3.11 (1.57-11.9) 3.87 ± 0.74 3.70 (3.05-5.27)
VZ/F (L) 666 ± 220 651 (342-1150) 702 ± 220 643 (456-1190)
VZ/F (L/kg) 9.85 ± 4.5 8.68 (5.02-22.5) 10.1 ± 2.6 9.63 (6.61-14.6)
T1/2 (hr) 2.00 ± 0.71 1.88 (1.24-4.00) 1.80 ± 0.31 1.78 (1.34-2.20)
AUC0-LAST (hr × ng/mL) 379 ± 170 362 (128-664) 287 ± 60 303 (196-361)
AUC0-∞ (hr × ng/mL) 385 ± 170 370 (131-671) 294 ± 58 311 (199-365)
AUC0-∞/dose (kg × hr × ng/mL × mg) 339 ± 160 322 (83.8-638) 267 ± 48 270 (190-327)
Extrapolated AUC0-∞ (%) 1.75 ± 0.99 1.43 (0.90-4.26) 2.59 ± 2.2 1.71 (0.73-8.76)
  1. TLAG = absorption lag time, CMAX = maximum observed plasma drug concentration, TMAX = observed time to reach CMAX, CL/F = oral clearance, VZ/F = apparent oral volume of distribution based on the terminal phase, T1/2 = terminal elimination half-life, AUC0-LAST = area under the plasma concentration time curve after the first dose to the last sampling time, AUC0-∞ = area under the plasma concentration time curve after the first dose to infinity, and Extrapolated AUC0-∞ = percentage of AUC0-∞ due to extrapolation from last measured concentration to infinity.