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Table 2 Relationship between subjects' age, titre of anti-MSP1 antibodies, inhibition of binding of specific monoclonal antibodies and multiplicity of infection.

From: Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum Merozoite Surface Protein 1 types in individuals in Nigeria with sub-microscopic infection

Age (years) Total Number of Subjects aAntibodies to rMSP1 bmAb12.10 mAb12.8 cInfection
   Responders (%) Mean Log titre H (%) H (%) M S MOI
<1 38 23 (61) 2.21 7 (18) 8 (21) 14 23 1.5
1 - 5 24 20 (83) 2.35 2 (8) 7 (29) 12 11 1.8
6 - 15 36 34 (94) 2.69 33 (92) 13 (36) 27 8 2.2
>15 49 48 (98) 2.94 15 (31) 18 (37) 20 28 1.5
Total 147 125 (85) 2.60 57 (39) 46 (31) 73 70 1.7
  1. aAntibodies to rMSP1: Responders is the number of subjects with antibodies against recombinant MSP1,(%) is the percentage of the total.
  2. bmAb12.10 and mAb 12.8: H refers to the number of individuals with antibodies highly competitive with the mAb; (%) is the percentage of the total.
  3. cInfection: M refers to individuals with two or more parasite clones; S refers to individuals with only one parasite type detected. MOI is the mean multiplicity of infection based on MSP1 block 2 alleles.