Artesunate-mefloquine combination therapy in acute Plasmodium falciparum malaria in young children: a field study regarding neurological and neuropsychiatric safety

Table 2 Neuropsychiatric and neurological disorder examination at baseline

Symptom	Yes		No		ND
	N	%	N	%	N	%
Dizziness	93	43.7	120	56.3	.	.
Headache	85	39.9	114	53.5	14	6.6
Vertigo	14	6.6	191	89.7	8	3.8
Convulsions	.	.	213	100.0	.	.
Paraesthesia	1	1.2	77	93.9	4	4.9
Dysaethesia	.	.	78	95.1	4	4.9
Sleeplessness (insomnia)	85	39.9	128	60.1	.	.
Nightmares	2	6.5	28	90.3	1	3.2
Hyperactivity	18	8.5	195	91.5	.	.
Anxiety	26	12.2	187	87.8	.	.
Panic Attack	30	14.1	183	85.9	.	.
Unexplained sadness	23	10.8	190	89.2	.	.
Mood changes	25	11.7	188	88.3	.	.
Confusion	4	1.9	208	97.7	1	0.5
Aggressive behavior	19	8.9	194	91.1	.	.
Tension	12	5.6	201	94.4	.	.
Visual hallucinations	3	3.7	77	93.9	2	2.4
Acoustic hallucinations	.	.	78	95.1	4	4.9
Hearing loss	.	.	211	99.1	2	0.9
Dysarthria	3	1.4	205	96.2	5	2.3
Word finding disturbance (1)	.	.	200	93.9	13	6.1
Eating behavior	154	72.3	59	27.7	.	.
Swallowing disturbance	.	.	213	100.0	.	.
Tremor	.	.	205	96.2	8	3.8
Dystonia, ataxia	3	1.4	209	98.1	1	0.5
Hypereflexia	.	.	213	100.0	.	.
Hyporeflexia	8	3.8	205	96.2	.	.
Clonus	.	.	213	100.0	.	.
Dysdiadochokinesis	1	0.5	137	64.3	75	35.2
Disturbed vision	.	.	128	60.1	85	39.9
Nystagmus	.	.	192	90.1	21	9.9
Double vision	1	1.2	62	75.6	19	23.2
Acoustic acuity	1	0.5	100	53.8	85	45.7
Forgetfullness	1	0.5	70	32.9	142	66.7
Word finding disturbance (2)	1	1.2	68	82.9	13	15.9

Nightmares were only assessed in children 5 years in age or older
Paraesthesia, dysaethesia, visual and acoustic hallucinations, double vision and word finding disturbance (2) were only assessed in children 3.5 years in age or older
Acoustic acuity was only assessed in children 1.5 years in age and or older

ISSN: 1475-2875