Table 1 Studies of HRP-2 performance compared to microscopy, in P. falciparum endemic areas.
Reference | Location | Study population | Transmission (prevalence of positive blood smear in the study population) | Sensitivity | Specificity |
|---|---|---|---|---|---|
Beadle [8] | Kenya | Children aged 9 to 14 years | Hyperendemic (86%) | 87% | 88% |
Swathout[11] | Democratic Republic of Congo | Symptomatic children aged 6-59 months | Highly endemic and seasonal | 100% | 52% |
Huong [9] | Vietnam | Symptomatic and control individuals aged 4-60 years | Hyperendemic | 96% | 100% |
Guthmann [7] | Uganda | Symptomatic individuals | Hyperendemic (57%) | 97% | 88% |
Williams [12] | Tanzania | Symptomatic individuals of all age | Hyperendemic (32%) | 94% | 89% |
Shiff [10] | Tanzania | na | Holoendemic | 89% | 88% |