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Table 1 Comparative performance indicators of each RDT

From: Performance of three multi-species rapid diagnostic tests for diagnosis of Plasmodium falciparum and Plasmodium vivax malaria in Oromia Regional State, Ethiopia

  CareStart ParaScreen ICT Combo McNemar p value1
P. falciparum 2 n = 2137 n = 2137 n = 2137 CS-PS CS-ICT ICT-PS
Sensitivity (95% CI3) 85.6%
(81.2-89.4)
85.6%
(81.2-89.4)
85.6%
(81.2-89.4)
1.0 1.0 1.0
Specificity (95% CI) 92.4%
(91.1-93.6)
92.4%
(91.1-93.6)
92.7%
(91.4-93.8)
1.0 0.10 0.10
PPV (95% CI) 65.3%
(60.5-70.0)
65.3%
(60.5-70.0)
66.2%
(61.3-70.8)
1.0 0.76 0.76
NPV (95% CI) 97.5%
(96.6-98.2)
97.5%
(96.6-98.2)
97.5%
(96.6-98.2)
1.0 1.0 1.0
κ4 0.6910 0.6910 0.6976 1.0 0.70 0.70
Non-falciparum only 5 n = 2077 n = 2077 n = 2077 CS-PS CS-ICT ICT-PS
Sensitivity (95% CI) 85.0%
(79.9-89.2)
82.5%
(77.2-87.1)
85.0%
(79.9-89.2)
0.11 1.0 0.08
Specificity (95% CI) 97.2%
(96.4-97.9)
96.2%
(95.3-97.1)
96.7%
(95.8-97.5)
< 0.001 0.05 0.11
PPV (95% CI) 80.4%
(75.0-85.0)
74.7%
(69.0-79.7)
77.7%
(72.2-82.6)
0.10 0.39 0.43
NPV (95% CI) 98.0%
(97.2-98.6)
97.6%
(96.8-98.3)
98.0%
(97.2-98.6)
0.78 1.0 0.50
κ 0.8020 0.7531 0.7851 < 0.001 0.23 0.03
  1. 1 Significant relationships (p > 0.05) in bold type
  2. 2 Individuals with P. falciparum mono-infection or mixed infection with P. falciparum and P. vivax. P. vivax mono-infection excluded.
  3. 3 95% Confidence interval
  4. 4 Kappa (κ) is the proportion agreement between microscopy and RDT results, where 0.8 indicates good agreement.
  5. 5 Individuals with P. vivax mono-infection. Mixed infections and P. falciparum mono-infection excluded.