Performance of three multi-species rapid diagnostic tests for diagnosis of Plasmodium falciparum and Plasmodium vivax malaria in Oromia Regional State, Ethiopia

Table 1 Comparative performance indicators of each RDT

	CareStart	ParaScreen	ICT Combo	McNemar p value¹
*P. falciparum* ²	n = 2137	n = 2137	n = 2137	CS-PS	CS-ICT	ICT-PS
Sensitivity (95% CI³)	85.6% (81.2-89.4)	85.6% (81.2-89.4)	85.6% (81.2-89.4)	1.0	1.0	1.0
Specificity (95% CI)	92.4% (91.1-93.6)	92.4% (91.1-93.6)	92.7% (91.4-93.8)	1.0	0.10	0.10
PPV (95% CI)	65.3% (60.5-70.0)	65.3% (60.5-70.0)	66.2% (61.3-70.8)	1.0	0.76	0.76
NPV (95% CI)	97.5% (96.6-98.2)	97.5% (96.6-98.2)	97.5% (96.6-98.2)	1.0	1.0	1.0
κ⁴	0.6910	0.6910	0.6976	1.0	0.70	0.70
Non-falciparum only ⁵	n = 2077	n = 2077	n = 2077	CS-PS	CS-ICT	ICT-PS
Sensitivity (95% CI)	85.0% (79.9-89.2)	82.5% (77.2-87.1)	85.0% (79.9-89.2)	0.11	1.0	0.08
Specificity (95% CI)	97.2% (96.4-97.9)	96.2% (95.3-97.1)	96.7% (95.8-97.5)	< 0.001	0.05	0.11
PPV (95% CI)	80.4% (75.0-85.0)	74.7% (69.0-79.7)	77.7% (72.2-82.6)	0.10	0.39	0.43
NPV (95% CI)	98.0% (97.2-98.6)	97.6% (96.8-98.3)	98.0% (97.2-98.6)	0.78	1.0	0.50
κ	0.8020	0.7531	0.7851	< 0.001	0.23	0.03

¹ Significant relationships (p > 0.05) in bold type
² Individuals with P. falciparum mono-infection or mixed infection with P. falciparum and P. vivax. P. vivax mono-infection excluded.
³ 95% Confidence interval
⁴ Kappa (κ) is the proportion agreement between microscopy and RDT results, where 0.8 indicates good agreement.
⁵ Individuals with P. vivax mono-infection. Mixed infections and P. falciparum mono-infection excluded.

ISSN: 1475-2875