Skip to main content

Advertisement

Table 2 Sensitivities of RDTs at different parasite densities

From: Performance of three multi-species rapid diagnostic tests for diagnosis of Plasmodium falciparum and Plasmodium vivax malaria in Oromia Regional State, Ethiopia

   CareStart ParaScreen ICT Combo McNemar p value1
P. falciparum        
Parasite density N Sensitivity: Pf or Pf+pan2 (95% CI3) CS-PS CS-ICT ICT-PS
< 200 p/μl 63 66.7%
(53.7-78.1)
66.7%
(53.7-78.1)
66.7%
(53.7-78.1)
1.0 1.0 1.0
< 500 p/μl 90 70.0%
(59.4-79.2)
70.0%
(59.4-79.2)
70.0%
(59.4-79.2)
1.0 1.0 1.0
< 5000 p/μl 188 79.1%
(72.6-84.7)
79.1%
(72.6-84.7)
79.1%
(72.6-84.7)
1.0 1.0 1.0
> 5000 p/μl 118 95.8%
(90.4-98.6)
95.7%
(90.4-98.6)
95.7%
(90.4-98.6)
1.0 1.0 1.0
P. vivax        
Parasite density N Sensitivity: pan band only4 (95% CI) CS-PS CS-ICT ICT-PS
< 200 p/μl 9 77.8%
(40.0-97.2)
88.9%
(51.8-99.7)
66.7%
(29.9-92.5)
0.32 0.56 0.16
< 500 p/μl 28 82.1%
(63.1-93.9)
89.3%
(71.8-97.7)
85.7%
(67.3-96.0)
0.32 0.65 0.56
< 5000 p/μl 116 82.8%
(74.6-89.1)
82.8%
(74.6-89.1)
82.8%
(74.6-89.1)
1.0 1.0 1.0
> 5000 p/μl 128 86.7%
(79.6-92.1)
82.8%
(75.1-88.9)
86.7%
(79.6-92.1)
0.03 1.0 0.03
  1. 1 Significant relationships (p > 0.05) in bold type.
  2. 2 RDT result showed either P. falciparum HRP2 band only, or HRP2 band and pan pLDH band. Individuals with P. vivax infection only excluded.
  3. 3 95% Confidence Interval
  4. 4 RDT result showing pan band only. Individuals with any P. falciparum infection excluded.