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Table 2 Sensitivities of RDTs at different parasite densities

From: Performance of three multi-species rapid diagnostic tests for diagnosis of Plasmodium falciparum and Plasmodium vivax malaria in Oromia Regional State, Ethiopia

  

CareStart

ParaScreen

ICT Combo

McNemar p value1

P. falciparum

       

Parasite density

N

Sensitivity: Pf or Pf+pan2 (95% CI3)

CS-PS

CS-ICT

ICT-PS

< 200 p/μl

63

66.7%

(53.7-78.1)

66.7%

(53.7-78.1)

66.7%

(53.7-78.1)

1.0

1.0

1.0

< 500 p/μl

90

70.0%

(59.4-79.2)

70.0%

(59.4-79.2)

70.0%

(59.4-79.2)

1.0

1.0

1.0

< 5000 p/μl

188

79.1%

(72.6-84.7)

79.1%

(72.6-84.7)

79.1%

(72.6-84.7)

1.0

1.0

1.0

> 5000 p/μl

118

95.8%

(90.4-98.6)

95.7%

(90.4-98.6)

95.7%

(90.4-98.6)

1.0

1.0

1.0

P. vivax

       

Parasite density

N

Sensitivity: pan band only4 (95% CI)

CS-PS

CS-ICT

ICT-PS

< 200 p/μl

9

77.8%

(40.0-97.2)

88.9%

(51.8-99.7)

66.7%

(29.9-92.5)

0.32

0.56

0.16

< 500 p/μl

28

82.1%

(63.1-93.9)

89.3%

(71.8-97.7)

85.7%

(67.3-96.0)

0.32

0.65

0.56

< 5000 p/μl

116

82.8%

(74.6-89.1)

82.8%

(74.6-89.1)

82.8%

(74.6-89.1)

1.0

1.0

1.0

> 5000 p/μl

128

86.7%

(79.6-92.1)

82.8%

(75.1-88.9)

86.7%

(79.6-92.1)

0.03

1.0

0.03

  1. 1 Significant relationships (p > 0.05) in bold type.
  2. 2 RDT result showed either P. falciparum HRP2 band only, or HRP2 band and pan pLDH band. Individuals with P. vivax infection only excluded.
  3. 3 95% Confidence Interval
  4. 4 RDT result showing pan band only. Individuals with any P. falciparum infection excluded.