Performance of three multi-species rapid diagnostic tests for diagnosis of Plasmodium falciparum and Plasmodium vivax malaria in Oromia Regional State, Ethiopia

Table 2 Sensitivities of RDTs at different parasite densities

		CareStart	ParaScreen	ICT Combo	McNemar p value¹
P. falciparum
Parasite density	N	Sensitivity: Pf or Pf+pan² (95% CI³)			CS-PS	CS-ICT	ICT-PS
< 200 p/μl	63	66.7% (53.7-78.1)	66.7% (53.7-78.1)	66.7% (53.7-78.1)	1.0	1.0	1.0
< 500 p/μl	90	70.0% (59.4-79.2)	70.0% (59.4-79.2)	70.0% (59.4-79.2)	1.0	1.0	1.0
< 5000 p/μl	188	79.1% (72.6-84.7)	79.1% (72.6-84.7)	79.1% (72.6-84.7)	1.0	1.0	1.0
> 5000 p/μl	118	95.8% (90.4-98.6)	95.7% (90.4-98.6)	95.7% (90.4-98.6)	1.0	1.0	1.0
P. vivax
Parasite density	N	Sensitivity: pan band only⁴ (95% CI)			CS-PS	CS-ICT	ICT-PS
< 200 p/μl	9	77.8% (40.0-97.2)	88.9% (51.8-99.7)	66.7% (29.9-92.5)	0.32	0.56	0.16
< 500 p/μl	28	82.1% (63.1-93.9)	89.3% (71.8-97.7)	85.7% (67.3-96.0)	0.32	0.65	0.56
< 5000 p/μl	116	82.8% (74.6-89.1)	82.8% (74.6-89.1)	82.8% (74.6-89.1)	1.0	1.0	1.0
> 5000 p/μl	128	86.7% (79.6-92.1)	82.8% (75.1-88.9)	86.7% (79.6-92.1)	0.03	1.0	0.03

¹ Significant relationships (p > 0.05) in bold type.
² RDT result showed either P. falciparum HRP2 band only, or HRP2 band and pan pLDH band. Individuals with P. vivax infection only excluded.
³ 95% Confidence Interval
⁴ RDT result showing pan band only. Individuals with any P. falciparum infection excluded.