Skip to main content

Advertisement

Table 2 Association analysis of SNPs across the LTA/TNF/LTB gene locus genotyped in severe malaria cases and controls.

From: A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults

dbSNP rs Position Gene Role Alleles MAFa ORb (CI)c Associationd χ2 P- value
      Controls SM    
rs2857602 chr6:31641357 LTA Promoter G > A 0.27 0.27 1.02 (0.81-1.28) 0.02 1.000
rs3131637 chr6:31643053 LTA Promoter A > T 0.27 0.27 1.02 (0.81-1.28) 0.02 1.000
rs2844484 chr6:31644203 LTA Promoter A > G 0.27 0.27 1.03 (0.81-1.29) 0.05 1.000
rs2844483 chr6:31644775 LTA Promoter T > G 0.27 0.27 1.02 (0.81-1.28) 0.02 1.000
rs2009658 chr6:31646223 LTA Promoter C > G 0.25 0.26 1.05 (0.83-1.33) 0.14 1.000
rs2844482 chr6:31647746 LTA Promoter C > T 0.25 0.26 1.07 (0.85-1.35) 0.30 1.000
rs2071590 chr6:31647747 LTA Promoter A > G 0.44 0.49 1.25 (1.02-1.54) 4.52 0.366
rs1800683 chr6:31648050 LTA Promoter G > A 0.02 0.01 1.98 (0.72-5.35) 1.82 0.979
rs2239704 chr6:31648120 LTA Exon A > C 0.27 0.27 1.02 (0.81-1.29) 0.03 1.000
rs909253 chr6:31648292 LTA Intron (boundary) A > G 0.02 0.01 1.98 (0.73-5.36) 1.84 0.978
rs2857713 chr6:31648535 LTA Coding exon T > C 0.25 0.26 1.06 (0.84-1.34) 0.23 1.000
rs1041981 chr6:31648763 LTA Coding exon C > A 0.02 0.01 2.15 (0.80-5.77) 2.44 0.814
rs1799964 chr6:31650287 LTA 3' UTR T > C 0.25 0.27 1.07 (0.84-1.35) 0.30 1.000
rs1799724 chr6:31650461 LTA 3' UTR C > T 0.43 0.39 1.19 (0.97-1.47) 2.76 0.755
rs1800610 chr6:31651806 TNF Intron G > A 0.42 0.39 1.13 (0.92 - 1.40) 1.37 0.992
rs3091257 chr6:31654829 TNF 3' UTR C > A < 0.01 < 0.01 1.07 (0.07 - 17.11) < 0.01 1.000
rs769178 chr6:31655493 LTB 3' UTR C > A 0.43 0.39 1.20 (0.97 - 1.49) 2.98 0.682
rs769177 chr6:31655590 LTB 3' UTR G > A 0.04 0.05 1.11 (0.67 - 1.84) 0.15 1.000
rs1052248 chr6:31664560 LST1 Exon A > T 0.42 0.49 1.33 (1.08 -1.63) 7.22 0.098
  1. aMinor allele frequency.
  2. bOdds ratio.
  3. c95% confidence interval.
  4. dAssociation χ2 with severe malaria.