A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults

Malaria Journal

Table 2 Association analysis of SNPs across the LTA/TNF/LTB gene locus genotyped in severe malaria cases and controls.

dbSNP rs	Position	Gene	Role	Alleles	MAF^a		OR^b (CI)^c	Association^d χ²	P- value
					Controls	SM
rs2857602	chr6:31641357	LTA	Promoter	G > A	0.27	0.27	1.02 (0.81-1.28)	0.02	1.000
rs3131637	chr6:31643053	LTA	Promoter	A > T	0.27	0.27	1.02 (0.81-1.28)	0.02	1.000
rs2844484	chr6:31644203	LTA	Promoter	A > G	0.27	0.27	1.03 (0.81-1.29)	0.05	1.000
rs2844483	chr6:31644775	LTA	Promoter	T > G	0.27	0.27	1.02 (0.81-1.28)	0.02	1.000
rs2009658	chr6:31646223	LTA	Promoter	C > G	0.25	0.26	1.05 (0.83-1.33)	0.14	1.000
rs2844482	chr6:31647746	LTA	Promoter	C > T	0.25	0.26	1.07 (0.85-1.35)	0.30	1.000
rs2071590	chr6:31647747	LTA	Promoter	A > G	0.44	0.49	1.25 (1.02-1.54)	4.52	0.366
rs1800683	chr6:31648050	LTA	Promoter	G > A	0.02	0.01	1.98 (0.72-5.35)	1.82	0.979
rs2239704	chr6:31648120	LTA	Exon	A > C	0.27	0.27	1.02 (0.81-1.29)	0.03	1.000
rs909253	chr6:31648292	LTA	Intron (boundary)	A > G	0.02	0.01	1.98 (0.73-5.36)	1.84	0.978
rs2857713	chr6:31648535	LTA	Coding exon	T > C	0.25	0.26	1.06 (0.84-1.34)	0.23	1.000
rs1041981	chr6:31648763	LTA	Coding exon	C > A	0.02	0.01	2.15 (0.80-5.77)	2.44	0.814
rs1799964	chr6:31650287	LTA	3' UTR	T > C	0.25	0.27	1.07 (0.84-1.35)	0.30	1.000
rs1799724	chr6:31650461	LTA	3' UTR	C > T	0.43	0.39	1.19 (0.97-1.47)	2.76	0.755
rs1800610	chr6:31651806	TNF	Intron	G > A	0.42	0.39	1.13 (0.92 - 1.40)	1.37	0.992
rs3091257	chr6:31654829	TNF	3' UTR	C > A	< 0.01	< 0.01	1.07 (0.07 - 17.11)	< 0.01	1.000
rs769178	chr6:31655493	LTB	3' UTR	C > A	0.43	0.39	1.20 (0.97 - 1.49)	2.98	0.682
rs769177	chr6:31655590	LTB	3' UTR	G > A	0.04	0.05	1.11 (0.67 - 1.84)	0.15	1.000
rs1052248	chr6:31664560	LST1	Exon	A > T	0.42	0.49	1.33 (1.08 -1.63)	7.22	0.098

ISSN: 1475-2875