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Table 3 Comparison of measured and estimated parameters of parasite clearance

From: Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance

A. PCT (hr):

Patient (ID)

Drug

Micr.

observed

qPCR* observed

Micr.

LL

qPCR

LL

1 (OX007)

QN

120

-

122

134

2 (OX005)

QN

96

-

87

89

3 (OX006)

AS

120

-

121

183

4

QN; AP

-

-

220

199

B. PRR 48 h (ratio, no units):

Patient (ID)

Drug

Micr.

observed

qPCR * observed

Micr.

LL

qPCR

LL

1 (OX007)

QN

80

30

100

50

2 (OX005)

QN

100 000

100 000

25 000

25 000

3 (OX006)

AS

50

14

100

14

4

QN; AP

10

7

10

10

C. PCT 95 (hr):

Patient (ID)

Drug

Drug

Micr.

observed

qPCR * observed

Micr.

LL

qPCR

LL

1 (OX007)

QN

49

44

33

38

2 (OX005)

QN

16

16

15

15

3 (OX006)

AS

45

49

39

56

4

QN; AP

56

55

60

54

  1. PCT Parasite Clearance Time
  2. PRR48h Parasite Reduction Rate - ratio between admission count and 48 hours later
  3. PCT95 (hr) the time required to clear 95% of parasites
  4. LL log linear model for best fit
  5. * All samples reported negative by microscopy were positive by RT-PCR and hence PCT was not directly observed by RT-PCR