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Table 3 Comparison of measured and estimated parameters of parasite clearance

From: Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance

A. PCT (hr):
Patient (ID) Drug Micr.
observed
qPCR* observed Micr.
LL
qPCR
LL
1 (OX007) QN 120 - 122 134
2 (OX005) QN 96 - 87 89
3 (OX006) AS 120 - 121 183
4 QN; AP - - 220 199
B. PRR 48 h (ratio, no units):
Patient (ID) Drug Micr.
observed
qPCR * observed Micr.
LL
qPCR
LL
1 (OX007) QN 80 30 100 50
2 (OX005) QN 100 000 100 000 25 000 25 000
3 (OX006) AS 50 14 100 14
4 QN; AP 10 7 10 10
C. PCT 95 (hr):
Patient (ID)
Drug
Drug Micr.
observed
qPCR * observed Micr.
LL
qPCR
LL
1 (OX007) QN 49 44 33 38
2 (OX005) QN 16 16 15 15
3 (OX006) AS 45 49 39 56
4 QN; AP 56 55 60 54
  1. PCT Parasite Clearance Time
  2. PRR48h Parasite Reduction Rate - ratio between admission count and 48 hours later
  3. PCT95 (hr) the time required to clear 95% of parasites
  4. LL log linear model for best fit
  5. * All samples reported negative by microscopy were positive by RT-PCR and hence PCT was not directly observed by RT-PCR