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Table 2 Intention to treat analysis of outcomes for women randomized in the trial using Poisson regression analysis with robust error estimation (crude and adjusted Incident rate ratio).

From: Intermittent preventive treatment of malaria with sulphadoxine-pyrimethamine during pregnancy in Burkina Faso: effect of adding a third dose to the standard two-dose regimen on low birth weight, anaemia and pregnancy outcomes

  Prevalence (Proportion) of women with characteristics Crude IRR (95% CI) Adjusted IRR* (95% CI)
Characteristics SP2 group SP3 group
Overall     
   LBW 14.1 (73/519) 12.8 (66/515) 0.91 (0.67 - 1.24) 0.92 (0.69 - 1.24)
   Anaemia 44.8 (280/625) 44.5 (289/649) 0.99 (0.87 - 1.12) 0.99 (0.88 - 1.12)
   Severe anaemia 2.8 (18/625) 1.1 (7/649) 0.37 (0.16 - 0.89)a 0.38 (0.16 - 0.90)b
   Premature delivery (%) 18.2 (111/610) 18.3 (116/632) 1.00 (0.79 - 1.27) 0.97 (0.77 - 1.24)
   Spontaneous abortion (%) 2.8 (17/610) 3.8 (24/632) 1.36 (0.74 - 2.51) 1.36 (0.74 - 2.53)
   Stillbirth 1.6 (10/610) 2.7 (17/635) 1.63 (0.75 - 3.54) 1.64 (0.74 - 3.61)
   Neonatal death 2.1 (13/625) 2.8 (18/649) 1.33 (0.83 - 3.20) 1.32 (0.81 - 3.23)
Gravidae 1     
   LBW 30.6 (34/111) 33.3(33/99) 1.08 (0.73 - 1.61) 1.05 (0.71 - 1.56)
   Anaemia 47.4(64/135) 50.0 (65/130) 1.05 (0.82 - 1.35) 1.05 (0.82 - 1.34)
   Severe anaemia 5.2 (7/135) 1.5 (2/130) 0.29 (0.06 - 1.40) 0.29 (0.05 - 1.46)
   Premature delivery (%) 29.4 (38/129) 25.8 (33/128) 0.87 (0.58 - 1.30) 0.81 (0.55 - 1.18)
   Spontaneous abortion (%) 4.7 (6/129) 8.6 (11/128) 1.84 (0.70 - 4.85) 1.51 (0.59 - 3.86)
   Stillbirth 3.1 (4/129) 3.9 (5/128) 1.26 (0.34 - 4.59) 1.23 (0.30 - 4.89)
   Neonatal death 5.2 (7/135) 5.4 (7/130) 1.04 (0.37 - 2.88) 0.95 (0.32 - 2.82)
Gravidae 2-3     
   LBW 13.4 (24/179) 11.3 (21/186) 0.84 (0.48 - 1.45) 0.86 (0.50 - 1.46)
   Anaemia 45.1 (97/215) 39.0 (92/236) 0.86 (0.69 - 1.07) 0.88 (0.71 - 1.09)
   Severe anaemia 3.3 (7/215) 1.7 (4/236) 0.52 (0.15 - 1.75) 0.54 (0.16 - 1.84)
   Premature delivery (%) 17.6 (37/210) 20.9 (48/230) 1.18 (0.80 - 1.74) 1.10 (0.75 -1.60)
   Spontaneous abortion (%) 1.4 (3/209) 2.2 (5/230) 1.50 (0.36 - 6.27) 1.47 (0.38 - 5.62)
   Stillbirth 0.5 (1/209) 2.6 (6/232) 5.40 (0.65 - 44.63) 5.85 (0.66 - 51.31)
   Neonatal death 0.5 (1/215) 2.1 (5/236) 4.49 (1.04 - 34.32) 8.8 (1.08 - 51.49)
Gravidae ≥4     
   LBW 6.6 (15/229) 5.2 (12/230) 0.79 (0.38 - 1.66) 0.78 (0.37 - 1.64)
   Anaemia 43.3 (119/275) 46.6 (132/283) 1.07 (0.89 - 1.29) 1.06 (0.87 - 1.28)
   Severe anaemia 1.5 (4/275) 0.4 (1/283) 0.24 (0.03 - 2.16) 0.24 (0.03 - 2.16)
   Premature delivery (%) 13.3 (36/271) 12.8 (35/274) 0.96 (0.37 - 1.27) 0.95 (0.60 - 1.47)
   Spontaneous abortion (%) 2.9 (8/272) 2.9 (8/274) 0.99 (0.37 - 2.60) 0.99 (0.37 - 2.60)
   Stillbirth 1.8 (5/272) 2.2 (6/275) 1.18 ( 0.36- 3.84) 1.11 (0.34 - 3.63)
   Neonatal death 1.8 (5/275) 2.1 (6/283) 1.16 (0.35 - 3.78) 1.11 (0.34 - 3.62)
  1. *Adjusted for age category, BMI, malaria infection, malaria season at delivery, supplementation and parity category (the later for the overall analysis only), a p= 0.026, b p = 0.030