Skip to main content

Table 2 Intention to treat analysis of outcomes for women randomized in the trial using Poisson regression analysis with robust error estimation (crude and adjusted Incident rate ratio).

From: Intermittent preventive treatment of malaria with sulphadoxine-pyrimethamine during pregnancy in Burkina Faso: effect of adding a third dose to the standard two-dose regimen on low birth weight, anaemia and pregnancy outcomes

 

Prevalence (Proportion) of women with characteristics

Crude IRR

(95% CI)

Adjusted IRR*

(95% CI)

Characteristics

SP2 group

SP3 group

Overall

    

   LBW

14.1 (73/519)

12.8 (66/515)

0.91 (0.67 - 1.24)

0.92 (0.69 - 1.24)

   Anaemia

44.8 (280/625)

44.5 (289/649)

0.99 (0.87 - 1.12)

0.99 (0.88 - 1.12)

   Severe anaemia

2.8 (18/625)

1.1 (7/649)

0.37 (0.16 - 0.89)a

0.38 (0.16 - 0.90)b

   Premature delivery (%)

18.2 (111/610)

18.3 (116/632)

1.00 (0.79 - 1.27)

0.97 (0.77 - 1.24)

   Spontaneous abortion (%)

2.8 (17/610)

3.8 (24/632)

1.36 (0.74 - 2.51)

1.36 (0.74 - 2.53)

   Stillbirth

1.6 (10/610)

2.7 (17/635)

1.63 (0.75 - 3.54)

1.64 (0.74 - 3.61)

   Neonatal death

2.1 (13/625)

2.8 (18/649)

1.33 (0.83 - 3.20)

1.32 (0.81 - 3.23)

Gravidae 1

    

   LBW

30.6 (34/111)

33.3(33/99)

1.08 (0.73 - 1.61)

1.05 (0.71 - 1.56)

   Anaemia

47.4(64/135)

50.0 (65/130)

1.05 (0.82 - 1.35)

1.05 (0.82 - 1.34)

   Severe anaemia

5.2 (7/135)

1.5 (2/130)

0.29 (0.06 - 1.40)

0.29 (0.05 - 1.46)

   Premature delivery (%)

29.4 (38/129)

25.8 (33/128)

0.87 (0.58 - 1.30)

0.81 (0.55 - 1.18)

   Spontaneous abortion (%)

4.7 (6/129)

8.6 (11/128)

1.84 (0.70 - 4.85)

1.51 (0.59 - 3.86)

   Stillbirth

3.1 (4/129)

3.9 (5/128)

1.26 (0.34 - 4.59)

1.23 (0.30 - 4.89)

   Neonatal death

5.2 (7/135)

5.4 (7/130)

1.04 (0.37 - 2.88)

0.95 (0.32 - 2.82)

Gravidae 2-3

    

   LBW

13.4 (24/179)

11.3 (21/186)

0.84 (0.48 - 1.45)

0.86 (0.50 - 1.46)

   Anaemia

45.1 (97/215)

39.0 (92/236)

0.86 (0.69 - 1.07)

0.88 (0.71 - 1.09)

   Severe anaemia

3.3 (7/215)

1.7 (4/236)

0.52 (0.15 - 1.75)

0.54 (0.16 - 1.84)

   Premature delivery (%)

17.6 (37/210)

20.9 (48/230)

1.18 (0.80 - 1.74)

1.10 (0.75 -1.60)

   Spontaneous abortion (%)

1.4 (3/209)

2.2 (5/230)

1.50 (0.36 - 6.27)

1.47 (0.38 - 5.62)

   Stillbirth

0.5 (1/209)

2.6 (6/232)

5.40 (0.65 - 44.63)

5.85 (0.66 - 51.31)

   Neonatal death

0.5 (1/215)

2.1 (5/236)

4.49 (1.04 - 34.32)

8.8 (1.08 - 51.49)

Gravidae ≥4

    

   LBW

6.6 (15/229)

5.2 (12/230)

0.79 (0.38 - 1.66)

0.78 (0.37 - 1.64)

   Anaemia

43.3 (119/275)

46.6 (132/283)

1.07 (0.89 - 1.29)

1.06 (0.87 - 1.28)

   Severe anaemia

1.5 (4/275)

0.4 (1/283)

0.24 (0.03 - 2.16)

0.24 (0.03 - 2.16)

   Premature delivery (%)

13.3 (36/271)

12.8 (35/274)

0.96 (0.37 - 1.27)

0.95 (0.60 - 1.47)

   Spontaneous abortion (%)

2.9 (8/272)

2.9 (8/274)

0.99 (0.37 - 2.60)

0.99 (0.37 - 2.60)

   Stillbirth

1.8 (5/272)

2.2 (6/275)

1.18 ( 0.36- 3.84)

1.11 (0.34 - 3.63)

   Neonatal death

1.8 (5/275)

2.1 (6/283)

1.16 (0.35 - 3.78)

1.11 (0.34 - 3.62)

  1. *Adjusted for age category, BMI, malaria infection, malaria season at delivery, supplementation and parity category (the later for the overall analysis only), a p= 0.026, b p = 0.030