Modulating effects of plasma containing anti-malarial antibodies on in vitro anti-malarial drug susceptibility in Plasmodium falciparum

Table 1 Plasmodium falciparum parasitaemia in culture in the presence of plasma from healthy donors and 'immune' plasma

Plasma concentration	Median (range) % parasitaemia after 48 hours incubation *
Plasma concentration	Normal plasma	'Immune' plasma **
Control (MCM)	1.7 (1.5-2.6)	1.7 (1.4-2.3)
2.5%	1.6 (1.5-1.7)	1.7 (1.2-2.1)
5%	1.5 (1.4-1.6)	1.4 (0.7-1.4)
10%	1.5 (1.4-1.7)	1.1 (0.9-1.2) ***
20%	1.4 (1.3-1.4) ***	1.1 (0.5-1.2) ***
40%	1.2 (1-1.4) ***	0.9 (0.7-1.2) ***

*- The percentage of infected red blood cells counted per 1,000 red blood cells.
**- 'Immune' plasma (titre of 1:50)
***- Significant difference compared to control; p ≤ 0.05 (N = 4). MCM is malaria culture medium.

ISSN: 1475-2875