From: Analysis of the dihydrofolate reductase-thymidylate synthase gene sequences in Plasmodium vivax field isolates that failed chloroquine treatment
1996
1997
1998
1999
2000
2001
Total
Number of patients
71
568
2275
2537
2853
1614
9918
Failed treatment cases
2
12
45
65
121
59
304
Rate (%)
2.81
2.11
1.98
2.56
4.24
3.67
3.07