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Table 1 In vitro geometric mean IC50 data for antifolates in the follow-up study

From: Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya

Drug N Mean IC50
(ng/ml)
Range
(ng/ml)
Percent resistant
pyrimethamine 43 171 21-2028 16.3 (53.5)a
chlorcycloguanil 41 2 0.5-11  
proguanil 41 929 129-3376  
sulphadoxine 41 9310 890-48,153 51.2
dapsone 27 648 16-129 14.8
  1. a percent resistant using the intermediate level of susceptibility of 500 nM (124.5 ng/ml) as the cutoff