Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya

Table 2 In vitro geometric mean IC₅₀ data for quinolines in the follow-up study

Drug	N	Mean IC₅₀ (ng/ml)	Range (ng/ml)	Percent resistant
chloroquine	60	15.3	3-110	15
mefloquine	62	12.0	1-48	51.6
quinine	61	47.7	14-313	1.6 (4.9)^a
amodiaquine	54	7.4	3-24	0

^a percent resistant using the intermediate level of susceptibility of 500 nM (162.2 ng/ml) as the cutoff

ISSN: 1475-2875