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Table 2 In vitro geometric mean IC50 data for quinolines in the follow-up study

From: Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya

Drug N Mean IC50
(ng/ml)
Range
(ng/ml)
Percent resistant
chloroquine 60 15.3 3-110 15
mefloquine 62 12.0 1-48 51.6
quinine 61 47.7 14-313 1.6 (4.9)a
amodiaquine 54 7.4 3-24 0
  1. a percent resistant using the intermediate level of susceptibility of 500 nM (162.2 ng/ml) as the cutoff