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Table 1 Pfmdr1 and pfatpase6 haplotypes from Paragominas (PRG), Porto Velho (PV) and Manaus (MAN) isolates.

From: Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy

Gene

Haplotypes

n (n/locality)

%

Mutated codons

pfmdr1

(n = 85)

NEF/CD VY

82 (19/PRG, 33/PV, 30/MAN)

97

4

 

NEF/SD VY

1 (MAN)

1

3

 

Y EY/SNVD

1 (MAN)

1

1

 

NEY/SNVD

1 (MAN)

1

0

pfatpase6

(n = 65)

HLLE/AAGNKKSK

24 (6/PRG, 4/PV, 14/MAN)

37

0

 

HLLE/AS GNKKSK

23 (11/PRG, 12/MAN)

35

1

 

HLV E/AAGNKKSK

3 (PV)

5

1

 

HLV E/AS GNKKSK

15 (PV)

23

2

  1. Codon positions: pfmdr1 N86Y, E130K, Y184F, S1034C, N1042 D, V1109I, D1246Y (n = 85); pftapase6 H243Y, L263E, L402V, E431K, A623E, A630 S, G639 D, N683K, K716R, K776N, S769N, K771E (n = 65). The haplotype of 3D7 strain is underlined and the mutated codons are shown in bold characters.