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Table 1 Medications licensed and recommended for malaria chemoprophylaxis by various countries

From: The position of mefloquine as a 21st century malaria chemoprophylaxis

Medication approved and available for malaria chemoprophylaxis United States Canada United Kingdom France Germany Switzerland Japan Australia
Mefloquine licensed licensed licensed licensed licensed licensed Licensed but not approved for use in children Licensed but not approved for use in children <14 years old
Doxycycline* for age ≥8 years for age ≥8 years for age ≥12 years for age >8 years Off Label for age ≥8 years - for age >8 years
Atovaquone-proguanil licensed licensed licensed licensed licensed licensed - licensed
Primaquine Only licensed for radical cure but is recommended as primary prophylaxis in CDC guideline licensed - not recommended for primary prophylaxis - - not registered for primary prophylaxis not registered for primary prophylaxis -
Proguanil in combination with chloroquine - - licensed licensed ° licensed licensed - licensed
  1. Adapted from Chen L, Wilson M, Schlagenhauf [49]
  2. + = licensed for malaria chemoprophylaxis and available in country.
  3. - = not licensed for malaria chemoprophylaxis or not available.
  4. * In some countries, doxycycline is licensed for specific indications but not malaria chemoprophylaxis. In Germany it is often used for this indication but not licensed for malaria prophylaxis "OFF LABEL" use.
  5. ° A fixed combination of chloroquine (100 mg base) and proguanil (200 mg) is available as Savarine® in France