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Table 2 Current malaria chemoprophylactic regimens based on their applicability for risk groups

From: The position of mefloquine as a 21st century malaria chemoprophylaxis

Drug Efficacy° Tolerability Long-term travel Pregnancy Breastfeeding Small children <8 yrs Cost*
Mefloquine +++ +++ +++ +++ +++ +++
Atovaquone/Proguanil +++ +++ ++ - +++ +++ +
Doxycycline +++ +++ ++ - - - +++
Chloroquine/Proguanil + + + ++ ++ + ++
  1. ° Efficacy of less than 75% gives a score of +, efficacy over 90% gives a score of +++ (Efficacy scores valid except for limited multi-drug resistant areas on the Thai-Cambodian and Thai-Myanmer borders)
  2. *The lower the cost, the higher number of +, Weighting is arbitrary and can be modified to specific travellers and itineraries. In the table, emphasis is placed on risk groups.
  3. § Perceived tolerability is poor but serious adverse events are rare