The position of mefloquine as a 21st century malaria chemoprophylaxis

Malaria Journal

Table 2 Current malaria chemoprophylactic regimens based on their applicability for risk groups

Drug	Efficacy°	Tolerability	Long-term travel	Pregnancy	Breastfeeding	Small children <8 yrs	Cost*
Mefloquine	+++	+§	+++	+++	+++	+++	+++
Atovaquone/Proguanil	+++	+++	++	-	+++	+++	+
Doxycycline	+++	+++	++	-	-	-	+++
Chloroquine/Proguanil	+	+	+	++	++	+	++

° Efficacy of less than 75% gives a score of +, efficacy over 90% gives a score of +++ (Efficacy scores valid except for limited multi-drug resistant areas on the Thai-Cambodian and Thai-Myanmer borders)
*The lower the cost, the higher number of +, Weighting is arbitrary and can be modified to specific travellers and itineraries. In the table, emphasis is placed on risk groups.
§ Perceived tolerability is poor but serious adverse events are rare

ISSN: 1475-2875