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Table 4 Adverse events interfering with daily activity (% of users)

From: The position of mefloquine as a 21st century malaria chemoprophylaxis

Study

Population

Mefloquine

Doxycycline°

Atovaquone

Proguanil

Chloroquine

Proguanil

Phillips 1996

Australian

11.2

6.5

-

-

Schlagenhauf 1996

Swiss

11.2

-

-

-

Barrett 1996

UK

17

-

-

16

Steffen 1993

European

13

-

-

16

Hogh* 2000

International

-

-

0.2

2.0

Overbosch* 2001

International

5.0

-

1.0

-

Schlagenhauf 2003

International

10.5

5.9

6.7

12.4

  1. Adapted from Schlagenhauf P [18]
  2. * stopped taking anti-malarials
  3. ° more AE with hyclate than monohydrate