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Table 3 Pharmacokinetic parameters of pentoxifylline and its metabolite

From: Pentoxifylline as an adjunct therapy in children with cerebral malaria

 

PTX

(N = 10)

PTX metabolite

(N = 9)

Cmax (ng/mL)

151 (82 - 332)

94 (35 - 291)

Tmax (hours)

10 (2 - 24)

12 (4 - 24)

AUC0-24 (ng . h/L) *

2828 (1743 - 3052)

1567 (831 - 1585)

AUC0-∞ (ng . h/L) *

7641 (5123 - 9177)

2314 (852 - 2855)

  1. * Data restricted to seven subjects with sufficient data points
  2. Data are median (range)
  3. Cmax : maximum concentration; Tmax : time to maximum concentration;
  4. AUC0-24 : area under the curve (0 to 24 hours); AUC0-∞ : area under the curve (0 to infinity)
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Malaria Journal

ISSN: 1475-2875

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