Insecticide resistance and malaria transmission: infection rate and oocyst burden in Culex pipiens mosquitoes infected with Plasmodium relictum

Table 1 Insecticide resistant and susceptible strains used in the isogenic strain experiment.

Strain	IR mechanism	Alleles	Genetic background
SLAB	None	Ester⁰, ace-1^S	SLAB
SA2B2	Overproduction of esterases A2 and B2	Ester², ace-1^S	SLAB
SA4B4	Overproduction of esterases A4 and B4	Ester⁴, ace-1^S	SLAB
SR	Insensitive acetylcholinesterase	Ester⁰, ace-1^R	SLAB

The overproduction of esterases is controlled by a superlocus consisting of two loci (esterase A and esterase B) in complete linkage disequilibrium. Alleles for this locus are the wild type susceptible Ester⁰, or the insecticide resistant Ester² (overproduces the esterase A2 and B2 isozymes) and Ester⁴ (overproduces the esterase A4 and B4 isozymes). The modification of the acetylcholinesterase is controlled by the locus ace- 1. Alleles for this locus are the wild type susceptible ace-1^S and the insecticide resistant ace-1^R (which contains a single GGC→AGC point mutation that renders the acetylcholinesterase insensitive to the insecticide). For more details on those strains, see [4].

ISSN: 1475-2875