Table 2 Anti-malarial and toxicity data for compounds selected for secondary in vitro screening.*
From: Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols
WR# | IC90 Pf (ng/ml)* | LC50 RAW (μM)** | LC50 neurons (μM) | % A2A inhibition at 200 nM | % A1 inhibition at 200 nM | |||
|---|---|---|---|---|---|---|---|---|
| Â | W2 | D6 | C235 | C2A | Â | Â | Â | Â |
MQ | 6.2 +/- 2.8 (532) | 17 +/- 11(536) | 52 +/- 30 (367) | 74 +/- 32 (77) | 9.0 +/- 3.7 (27) | 41 | 62 | 4.0 |
308245 | 17 | 45 | 58 | 80 | 40 | > 120 | 0 | 0 |
308255 | 3.8 | 15 | 19 | 37 | 58 | > 120 | NT | NT |
308257 | 4.7 | 23 | 23 | 39 | 14 | > 120 | 17 | 79 |
308266 | 6.1 | 25 | 24 | 52 | 13 | 59 | NT | NT |
308278 | 9.7 | 36 | 39 | 54 | 21 | > 120 | 1 | 9.4 |
308396 | 6.2 | 29 | 40 | 48 | 18 | 52 | 0 | 2.9 |
308446 | < 1 | 14 | 19 | 16 | 8.9 | 48 | NT | NT |
398387 | 1.2 | 7 | 12 | 11 | 21 | > 120 | NT | NT |
308388 | 1.1 | 6.7 | 11 | 10 | 16 | 56 | NT | NT |
308413 | 1.1 | 12 | 15 | 7.5 | 8.5 | > 120 | NT | NT |