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Table 2 Anti-malarial and toxicity data for compounds selected for secondary in vitro screening.*

From: Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

WR# IC90 Pf (ng/ml)* LC50 RAW (μM)** LC50 neurons (μM) % A2A inhibition at 200 nM % A1 inhibition at 200 nM
  W2 D6 C235 C2A     
MQ 6.2 +/- 2.8 (532) 17 +/- 11(536) 52 +/- 30 (367) 74 +/- 32 (77) 9.0 +/- 3.7 (27) 41 62 4.0
308245 17 45 58 80 40 > 120 0 0
308255 3.8 15 19 37 58 > 120 NT NT
308257 4.7 23 23 39 14 > 120 17 79
308266 6.1 25 24 52 13 59 NT NT
308278 9.7 36 39 54 21 > 120 1 9.4
308396 6.2 29 40 48 18 52 0 2.9
308446 < 1 14 19 16 8.9 48 NT NT
398387 1.2 7 12 11 21 > 120 NT NT
308388 1.1 6.7 11 10 16 56 NT NT
308413 1.1 12 15 7.5 8.5 > 120 NT NT
  1. * For mefloquine IC90s are presented as mean +/- standard deviation (n). ** RAW refers to the murine RAW macrophage cell line. For mefloquine LC50 is presented as mean +/- standard deviation (n).