Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

Malaria Journal

Table 4 Physiochemical properties of potent, active and inactive compounds

Parameter*	Active Compounds with IC90s < 250 nM	Active Compounds with IC90s < 540 ng/ml or 1000 nM	Inactive Compounds (IC90s > 540 ng/ml or 1000 nM)
	Mean +/- STDEV (N)	Mean +/- STDEV (N)	Mean +/- STDEV (N)
MW	410 +/- 35 (25)**#	444 +/- 37 (66)	435 +/- 45 (107)
LogD	3.6 +/- 0.77 (24)	3.6 +/- 1.2 (66)	3.9 +/- 1.3 (106)
PSA	48 +/- 9.6 (25)**	57 +/- 18 (66)**	66 +/- 19 (106)
LogP	3.5 +/- 0.88 (25)	3.4 +/- 1.2 (66)	2.9 +/- 1.5 (106)
FRBs	6.3 +/- 1.7 (25)	6.5 +/- 1.7 (66)**	5.8 +/- 1.8 (106)
HBDs	1.8 +/- 0.55 (25)	1.8 +/- 0.8 (66)	2.0 +/- 0.98 (106)
HBAs	3.2 +/- 0.52 (25)**#	4.0 +/- 0.89 (66)	4.4 +/- 1.3 (106)

* MW is molecular weight, PSA = polar surface area, FRBs = freely rotatable bonds, HBDs = H-bond donors, HBAs = H bond acceptors and LVs = Lipinski violations. Significant differences from inactive compounds or compounds with IC90s < 540 ng/ml/1000 nM# (one way ANOVA followed Bonferroni post-test, P < 0.05) are denoted by the symbols ** and # respectively.

ISSN: 1475-2875