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Table 5 Proportions of different functional groups present in active and inactive amines

From: Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

Chemical Property Number of Analogs in Subset of Active or Inactive Amines* P value**
  Active (# of 69) (%) Inactive (# of 129) (%)  
N or OH Replacement 1 (1.4) 12 (9.3) 0.036
Conjugated Amines 9 (13) 49 (38) 0.0003
Benzyl Amines 15 (22) 19 (15) 0.238
Side-chain Contains Heteroatoms 36 (52) 96 (74) 0.0025
Tertiary Amines 20 (29) 31 (24) 0.4964
Secondary Amines 49 (71) 78 (60) 0.0129
All Carbon Side-chain 21 (30) 8 (6.2) < 0.0001
  1. * An active compounds is one with an IC90 < 1000 nM against Pf C2A. ** Fisher's exact, P < 0.05 considered significant.