Table 4 Predictors of delay in parasite clearance on day 1 after treatment in children with acute falciparum malaria

Axillary temperature (°C)

   <38.0

2326

1012

1

1

   ≥ 38.0

228

139

2.02 (1.53 -2.67)

<0.0001

1.80 (1.30-2.50)

< 0.001

Parasitaemia (/μl blood)

≤ 20,000

1328

463

1

1

>20,000

683

467

5.25 (4.20 - 6.48)

<0.0001

5.13 (4.14 - 6.35)

< 0.001

Drug treatment *

CQ

388

275

1

1

1

AQ

573

298

0.44 (0.33 - 0.58)

<0.0001

0.79 (0.63 - 0.98)

< 0.03

AQAS

142

14

0.05 (0.03 - 0.08)

<0.0001

0.24 (0.10 - 0.57)

< 0.0001

AQPS

69

26

0.24 (0.14 - 0.42)

<0.0001

0.44 (0.26 - 0.73)

0.002

AQSP

91

34

0.25 (0.15 - 0.39)

<0.0001

0.43 (0.29 - 0.68)

< 0.0001

AMQ

174

10

0.03 (0.01 - 0.05)

<0.0001

0.04 (0.02 - 0.09)

< 0.0001

AL

90

6

0.03 (0.01 - 0.07)

<0.0001

0.05 (0.02 - 0.12)

< 0.0001

AS

120

3

0.01 (0.00 - 0.03)

<0.0001

0.02 (0.00 - 0.06)

< 0.0001

COT

104

61

0.58 (0.37 - 0.91)

0.017

1.03 (0.68 - 1.36)

0.877

CQCP

315

189

0.61 (0.45 - 0.84)

0.002

1.09 (0.83 - 1.42)

0.512

CQKET

70

36

0.43 (0.25 - 0.73)

0.001

0.77 (0.47 - 1.25)

0.029

CQPS

107

46

0.31 (0.19 - 0.48)

<0.0001

0.54 (0.36 - 0.82)

0.004

MQ

176

40

0.12 (0.08 - 0.18)

<0.0001

0.21 (0.15 - 0.31)

< 0.0001

SP

291

186

0.72 (0.52 - 1.00)

0.055

-

-

SPP

42

13

0.18 (0.09 - 0.37)

<0.0001

0.33 (0.17 -0.98)

0.001