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Table 2 Outcome of intent-to-treat and per-protocol analyses on day 28 with PCR distinction between recrudescence and reinfection.

From: Efficacy of non-artemisinin- and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon

Comparator1 Treatment PCR-uncorrected outcome PCR-corrected outcom
OR (ITT) OR (PP) OR (ITT) OR (PP)
AS-AQ AQ 0.71 (0.31-1.60) 0.70 (0.26-1.85) 1.24 (0.43-3.56) 3.85 (0.41-35.6)
AS-AQ AS-SP 0.60 (0.23-1.31) 0.55 (0.20-1.53) 0.98 (0.32-3.00) 2.94 (0.30-29.2)
AQ-SP AS-MQ 0.68 (0.26-1.75) 0.13 (0.01-1.10) 1.62 (0.50-5.24) - -
AS-AQ AM-LM 0.26 (0.07-1.03) 0.36 (0.06-1.92) 0.13 (0.01-1.10) 0.12 (0-2.04)
AS-CD AS-SP 0.30* (0.13-0.62) 0.24* (0.09-0.65) 0.39* (0.17-0.85) 0.37 (0.12-1.20)
AS-AQ DH-PP 0.32* (0.12-0.80) 0.12* (0.02-0.52) 0.61 (0.22-1.66) 0.28 (0.05-1.36)
  1. Treatment outcome on day 28 for studies conducted in 2005-2007. OR (ITT), odds ratio in the case of the intention-to-treat (ITT) analysis, where the total number of patients enrolled was considered. OR (PP), odds ratio in the per-protocol (PP) analysis.
  2. 1Treatment taken as reference. Odds-ratios (OR, 95% confidence intervals in parentheses) were calculated for the pairs of ACT in each randomized study, except for the study in 2005 (AS-AQ vs AQ). Asterisks denote P < 0.05.