Efficacy of non-artemisinin- and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon

Table 2 Outcome of intent-to-treat and per-protocol analyses on day 28 with PCR distinction between recrudescence and reinfection.

Comparator¹	Treatment	PCR-uncorrected outcome		PCR-corrected outcom
Comparator¹	Treatment	OR (ITT)	OR (PP)	OR (ITT)	OR (PP)
AS-AQ	AQ	0.71 (0.31-1.60)	0.70 (0.26-1.85)	1.24 (0.43-3.56)	3.85 (0.41-35.6)
AS-AQ	AS-SP	0.60 (0.23-1.31)	0.55 (0.20-1.53)	0.98 (0.32-3.00)	2.94 (0.30-29.2)
AQ-SP	AS-MQ	0.68 (0.26-1.75)	0.13 (0.01-1.10)	1.62 (0.50-5.24)	- -
AS-AQ	AM-LM	0.26 (0.07-1.03)	0.36 (0.06-1.92)	0.13 (0.01-1.10)	0.12 (0-2.04)
AS-CD	AS-SP	0.30* (0.13-0.62)	0.24* (0.09-0.65)	0.39* (0.17-0.85)	0.37 (0.12-1.20)
AS-AQ	DH-PP	0.32* (0.12-0.80)	0.12* (0.02-0.52)	0.61 (0.22-1.66)	0.28 (0.05-1.36)

Treatment outcome on day 28 for studies conducted in 2005-2007. OR (ITT), odds ratio in the case of the intention-to-treat (ITT) analysis, where the total number of patients enrolled was considered. OR (PP), odds ratio in the per-protocol (PP) analysis.
¹Treatment taken as reference. Odds-ratios (OR, 95% confidence intervals in parentheses) were calculated for the pairs of ACT in each randomized study, except for the study in 2005 (AS-AQ vs AQ). Asterisks denote P < 0.05.

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