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Figure 5 | Malaria Journal

Figure 5

From: Dual effect of Plasmodium-infected erythrocytes on dendritic cell maturation

Figure 5

The schizont stage of P. yoelii -infected erythrocytes inhibit DC maturation in response to LPS. Bone-marrow derived DC were incubated for 24 h in different conditions and then further stimulated with LPS (black bars) or not (white bars) for 18 h. (A) CD86 expression of DC co-incubated with iRBC at the schizont stage (Sch), the trophozoite stage (Trophs), a mix of uninfected RBC and rings (Uninf+rings), fixed iRBC, saponized iRBC or isolated food vacuoles (FV) for 24 h, followed by addition of LPS and incubation for another 18 h. (B) CD86 expression of DC incubated with iRBC for 0-3, 0-24 or 0-48 h, with addition of LPS at 24 h. Data correspond to the average of triplicate samples ± standard deviation and figures are representative of one out of two independent experiments.

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