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Table 2 Effect of NeemAzal® on P. berghei oocyst prevalence and density on mosquito midguts.

From: Transmission blocking activity of a standardized neem (Azadirachta indica) seed extract on the rodent malaria parasite Plasmodium berghei in its vector Anopheles stephensi

Treatment*

Experiment †

% Prevalence (CI 95 )

Oocysts/mosquito (CI 95 ) #

Examined mosquitoes

control

1

90 (81 - 99)

17.5 (11.1 - 27.2)

40

 

2

83 (68 - 99)

29.9 (15.8 - 55.8)

24

 

3

100

111.2 (83.8 - 148.9)

40

 

4

86 (72 - 100)

35.2 (21.6 - 57.6)

22

 

5

88 (78 - 98)

11.3 (7.2 - 17.4)

42

 

6

89 (80 - 97)

26.1 (15.8 - 42.4)

53

 

tot ‡

90 (86 - 94)

27.7 (22.3 - 34.2)

221

NA 13.2 mg/kg

4

82 (64 - 100)

49.9 (24.5 - 100.5)

17

 

5

79 (66 - 91)

12.7 (8.6 - 18.7)

42

 

6

100

39.4 (30.5 - 50.9)

58

 

tot

90 (84 - 95)

28.9 (23.0 - 36.3)

117

NA 25 mg/kg

3

90 (81 - 99)

42.8 (26.7 - 69.1)

40

 

5

69 (55 - 84)

8.9 (5.4 - 14.2)

39

 

6

96 (91 - 100)

30.5 (22.3 - 41.1)

54

 

tot

86 (81 - 92)

25.6 (19.9 - 32.8)

133

NA 50 mg/kg

1

0

0

55

 

2

0

0

43

 

3

0

0

40

 

tot

0

0

138

AZA 50 mg/kg

3

95 (88 - 100)

23.3 (15.0 - 36.0)

41

 

5

88 (78 - 98)

24.3 (17.2 - 34.5)

42

 

6

83 (68 - 99)

3.2 (2.0 - 5.0)

24

 

tot

90 (73 - 100)

16.1 (12.2 - 21.2)

107

  1. Oocyst prevalence and intensity was assessed on day 10 after the infective blood meal carried out on mice treated with the indicated products and doses. * NA = NeemAzal® technical grade (Trifolio-M GmbH); AZA = azadirachtin tech grade (Sigma). † each number corresponds to one experimentation involving different treatment groups. # geometric means, only positive mosquitoes included. ‡ values refer to pooled data.