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Table 2 Effect of NeemAzal® on P. berghei oocyst prevalence and density on mosquito midguts.

From: Transmission blocking activity of a standardized neem (Azadirachta indica) seed extract on the rodent malaria parasite Plasmodium berghei in its vector Anopheles stephensi

Treatment* Experiment % Prevalence (CI 95 ) Oocysts/mosquito (CI 95 ) # Examined mosquitoes
control 1 90 (81 - 99) 17.5 (11.1 - 27.2) 40
  2 83 (68 - 99) 29.9 (15.8 - 55.8) 24
  3 100 111.2 (83.8 - 148.9) 40
  4 86 (72 - 100) 35.2 (21.6 - 57.6) 22
  5 88 (78 - 98) 11.3 (7.2 - 17.4) 42
  6 89 (80 - 97) 26.1 (15.8 - 42.4) 53
  tot 90 (86 - 94) 27.7 (22.3 - 34.2) 221
NA 13.2 mg/kg 4 82 (64 - 100) 49.9 (24.5 - 100.5) 17
  5 79 (66 - 91) 12.7 (8.6 - 18.7) 42
  6 100 39.4 (30.5 - 50.9) 58
  tot 90 (84 - 95) 28.9 (23.0 - 36.3) 117
NA 25 mg/kg 3 90 (81 - 99) 42.8 (26.7 - 69.1) 40
  5 69 (55 - 84) 8.9 (5.4 - 14.2) 39
  6 96 (91 - 100) 30.5 (22.3 - 41.1) 54
  tot 86 (81 - 92) 25.6 (19.9 - 32.8) 133
NA 50 mg/kg 1 0 0 55
  2 0 0 43
  3 0 0 40
  tot 0 0 138
AZA 50 mg/kg 3 95 (88 - 100) 23.3 (15.0 - 36.0) 41
  5 88 (78 - 98) 24.3 (17.2 - 34.5) 42
  6 83 (68 - 99) 3.2 (2.0 - 5.0) 24
  tot 90 (73 - 100) 16.1 (12.2 - 21.2) 107
  1. Oocyst prevalence and intensity was assessed on day 10 after the infective blood meal carried out on mice treated with the indicated products and doses. * NA = NeemAzal® technical grade (Trifolio-M GmbH); AZA = azadirachtin tech grade (Sigma). each number corresponds to one experimentation involving different treatment groups. # geometric means, only positive mosquitoes included. values refer to pooled data.