Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance

Table 2 Statistical tests of differences in allele and haplotype frequencies

Source of variation	Site	Locus		Likelihood ratio tests of differences in haplotype frequencies
Source of variation	Site	Locus	overall	pfcrt	pfmdr1	pfdhfr	pfdhps
Difference between health centre	Karimui	test statistic	0.004	6.9	0.0	6.3	0.7
and community samples		d.f.	n.a.	7	7	3	3
		P-value	0.3	0.4	1.0	0.1	0.9
	South Wosera	test statistic	0.011	30.1	2.3	14.3	14.6
		d.f.	n.a.	7	3	3	3
		P-value	0.02	<0.01	0.5	0.002	0.002
Difference between years	Karimui	test statistic	0.035	44.4	2.5	47.8	21.5
(community samples)		d.f.	n.a.	14	14	6	6
		P-value	<0.01	<0.01	1.0	<0.01	0.002
	South Wosera	test statistic	0.011	44.8	14.6	16.4	12
		d.f.	n.a.	7	3	3	3
		P-value	0.01	<0.01	0.002	0.001	0.007

ISSN: 1475-2875